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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Hereditary diffuse leukoencephalopathy with spheroids


Other Names for this Disease

  • Adult-onset leukodystrophy with neuroaxonal spheroids
  • Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia
  • Autosomal dominant leukoencephalopathy with neuroaxonal spheroids
  • HDLS
  • Hereditary diffuse leukoencephalopathy with axonal spheroids
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Inheritance

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How is hereditary diffuse leukoencephalopathy with spheroids (HDLS) inherited?

HDLS is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In most cases, an affected person inherits the mutation from one affected parent. Other cases result from new mutations in the gene and occur in people with no history of the disorder in their family.[1]
Last updated: 3/27/2013

References
  1. Hereditary diffuse leukoencephalopathy with spheroids. Genetics Home Reference (GHR). December 2012; http://ghr.nlm.nih.gov/condition/hereditary-diffuse-leukoencephalopathy-with-spheroids. Accessed 3/27/2013.


Other Names for this Disease
  • Adult-onset leukodystrophy with neuroaxonal spheroids
  • Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia
  • Autosomal dominant leukoencephalopathy with neuroaxonal spheroids
  • HDLS
  • Hereditary diffuse leukoencephalopathy with axonal spheroids
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.