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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Chronic graft versus host disease


Other Names for this Disease
  • Chronic GVHD
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Overview


Chronic graft versus host disease (GVHD) is a complication that can occur after a stem cell or bone marrow transplant in which the newly transplanted donor cells attack the transplant recipient's body.[1] Symptoms may include skin rash, mouth sores, dry eyes, liver inflammation, development of scar tissue in the skin and joints, and damage to the lungs.[1][2] The exact cause of chronic GVHD is unknown.[2] It likely results from a complex immune-mediated interaction between the donor and recipient cells.[2][3] Chronic GVHD is treated with prednisone or other similar anti-inflammatory or immunosuppressive medications.[1][2]  
Last updated: 2/21/2013

References

  1. Graft-versus-host disease. MedlinePlus. June 2012; http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm. Accessed 2/21/2013.
  2. Chronic Graft-versus-host disease. Chronic Graft Versus Host Disease Consortium. http://rarediseasesnetwork.epi.usf.edu/cGVHD/chronic/. Accessed 2/21/2013.
  3. Mandanas RA. Graft Versus Host Disease. Medscape Reference. December 2012; http://emedicine.medscape.com/article/429037-overview. Accessed 2/21/2013.
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Basic Information

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