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Genetic and Rare Diseases Information Center (GARD)

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Collagenous gastritis


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Overview



What is collagenous gastritis?

How might collagenous gastritis be treated?


What is collagenous gastritis?

Collagenous gastritis (CG) is a rare condition that primarily affects the gastrointestinal (GI) system. Individuals with CG have increased collagen deposition in the subepithelial layer of the stomach with infiltration of inflammatory cells in the gastric mucosa (mucous membrane layer of the stomach).[1][2] This condition typically affects children and young adults up to 22 years or older adults over 35 years of age; features appear to differ depending on the age group affected. Signs and symptoms in children and young adults often begin with anemia and abdominal pain, whereas older adults have loose stools frequently associated with collagenous colitis, celiac disease or both.[1] The cause of the condition is unknown.[1] There is currently no effective treatment.[2]
Last updated: 5/31/2013

How might collagenous gastritis be treated?

To our knowledge, there is currently no establishted method of treatment for collagenous gastritis (CG).[1][3] Various therapies have been attempted with some success.[4]

Some individuals with CG and celiac disease have reportedly had some relief of symptoms with gluten-free diets; however, this might have been related to the celiac disease rather than the CG itself. Budesonide has been used to treat collagenous colitis (a related disorder), and some symptomatic relief in individuals with CG treated with this medication has also been reported.[4] In a recent case report, symptoms of a young adult with CG stabilized with treatment of 10 mg of rabeprazole taken in the morning and evening before eating. Once his condition stabilized the dose was reduced to 10 mg once a day before breakfast. With this treatment and lifestyle improvements this patient's symptoms greatly improved.[3] As a result, it has been suggested that proton pump inhibitors, like rabeprazole, may be beneficial in treating this disorder.[3]
Last updated: 3/19/2013

References
  1. Brain O, Rajaguru C, Warren B, Booth J, Travis S. Collagenous gastritis: reports and systematic review. Eur J Gastroenterol Hepatol. December 2009; 21(12):1419-1424.
  2. Kori M, Cohen S, Levine A, Givony S, Sokolovskaia-Ziv N, Melzer E, Granot E. Collagenous gastritis: a rare cause of abdominal pain and iron-deficiency anemia. J Pediatr Gastroenterol Nutr. November 2007; 45(5):603-606.
  3. Jin X, Koike T, Chiba T, Kondo Y, Ara N, Uno K, Asano N, Iijima K, Imatani A, Watanabe M, Shirane A, Shimosegawa T. Collagenous Gastritis. Dig Endosc. 2012 Oct 22; http://www.ncbi.nlm.nih.gov/pubmed/?term=23363075. Accessed 3/19/2013.
  4. Leung ST, Chandan VS, Murray JA, Wu TT. Collagenous gastritis: histopathologic features and association with other gastrointestinal diseases. Am J Surg Pathol. May 2009; 33(5):788-798.