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Genetic and Rare Diseases Information Center (GARD)

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Collagenous gastritis


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Overview

Collagenous gastritis (CG) is a rare condition that primarily affects the gastrointestinal (GI) system. Individuals with CG have increased collagen deposition in the subepithelial layer of the stomach with infiltration of inflammatory cells in the gastric mucosa (mucous membrane layer of the stomach).[1][2] This condition typically affects children and young adults up to 22 years or older adults over 35 years of age; features appear to differ depending on the age group affected. Signs and symptoms in children and young adults often begin with anemia and abdominal pain, whereas older adults have loose stools frequently associated with collagenous colitis, celiac disease or both.[1] The cause of the condition is unknown.[1] There is currently no effective treatment.[2]
Last updated: 5/31/2013

References

  1. Brain O, Rajaguru C, Warren B, Booth J, Travis S. Collagenous gastritis: reports and systematic review. Eur J Gastroenterol Hepatol. December 2009; 21(12):1419-1424.
  2. Kori M, Cohen S, Levine A, Givony S, Sokolovskaia-Ziv N, Melzer E, Granot E. Collagenous gastritis: a rare cause of abdominal pain and iron-deficiency anemia. J Pediatr Gastroenterol Nutr. November 2007; 45(5):603-606.
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