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Diseases

Genetic and Rare Diseases Information Center (GARD)

Other Names for this Disease
  • Female Pseudo-Turner Syndrome
  • Male Turner Syndrome
  • Noonan-Ehmke syndrome
  • Pseudo-Ullrich-Turner syndrome
  • Ullrich-Noonan syndrome
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Inheritance


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How is Noonan syndrome inherited?

Noonan syndrome is inherited in an autosomal dominant manner, which means one copy of the altered gene in each cell is sufficient to cause the condition.[1][2][3] Each child of an individual with Noonan syndrome has a 50% (1 in 2) chance to inherit the condition.

In about one-third to two-thirds of families, one of the parents also has Noonan syndrome.[2] In other families, the condition results from a new mutation in the gene and there is no history of the condition in the family.[1]
Last updated: 10/1/2013

References
  1. Noonan syndrome. Genetics Home Reference (GHR). 2007; http://ghr.nlm.nih.gov/condition=noonansyndrome. Accessed 3/2/2010.
  2. Learning About Noonan Syndrome. National Human Genome Research Institute (NHGRI). 2009; http://www.genome.gov/25521674. Accessed 3/2/2010.
  3. Allanson JE. Noonan Syndrome. GeneReviews. 2008; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=noonan. Accessed 3/2/2010.