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Localized hypertrophic neuropathy

Other Names for this Disease
  • Onion whorl disease
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Localized hypertrophic neuropathy is a nerve condition in which nerve cells increase in number and form bundles that look like onion bulbs.  This condition affects one nerve, usually in an arm or leg.  The symptoms of this condition include muscle weakness, numbness, and decreased reflexes in the affected limb.  Symptoms slowly get worse over time.[1]  The cause of this condition is unknown, but some researchers believe it might be a type of tumor, while others believe it might be an unusual reaction to injury.[2]
Last updated: 7/9/2012


  1. Simmons Z, Mahadeen ZI, Kothari MJ, Powers S, Wise S, Towfighi J. Localized hypertrophic neuropathy: magnetic resonance imaging findings and long-term follow-up. Muscle & Nerve. 1999; 22:28-36. Accessed 7/6/2012.
  2. Koszyca B, Jones N, Kneebone C, Blumbergs P. Localized hypertrophic neuropathy: a case report and review of the literature. Clinical Neuropathology. 2009; 28:54-58. Accessed 7/5/2012.
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