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Genetic and Rare Diseases Information Center (GARD)

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Hereditary diffuse gastric cancer

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Other Names for this Disease
  • Gastric cancer, familial diffuse
  • Gastric cancer, hereditary diffuse
  • HDGC
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What is hereditary diffuse gastric cancer?

How is hereditary diffuse gastric cancer inherited?

What is hereditary diffuse gastric cancer?

Hereditary diffuse gastric cancer is an inherited cancer syndrome that greatly increases the chance of developing cancer of the stomach lining. This syndrome is caused by mutations in the CDH1 gene. In hereditary diffuse gastric cancer, stomach cancer typically develops in a person's late thirties or early forties. Mutations in the CDH1 gene also increase a person's risk for lobular breast cancer. This condition is inherited in an autosomal dominant pattern.[1]
Last updated: 12/16/2011

How is hereditary diffuse gastric cancer inherited?

Hereditary diffuse gastric cancer is inherited in an autosomal dominant pattern, which means that one inherited copy of the altered gene in each cell is sufficient to increase cancer risk. It is important to note that people inherit an increased risk of cancer, not the disease itself. Not all people who inherit mutations in this gene will develop cancer.[1]
Last updated: 12/16/2011

  1. Kaurah P, Huntsman DG. Hereditary diffuse gastric cancer. GeneReviews. June 2011; Accessed 9/30/2011.