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Genetic and Rare Diseases Information Center (GARD)

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Non-involuting congenital hemangioma

Other Names for this Disease
  • NICH
  • Noninvoluting congenital hemangioma
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Tests & Diagnosis

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How is non-involuting congenital hemangioma diagnosed?

Non-involuting congenital hemangioma (NICH) is diagnosed by taking a biopsy of the skin mark and examining the tissue under a microscope.  NICH looks different under the microscope than most infantile hemangiomas because the blood vessels are arranged more irregularly.  Also, the cells in an NICH do not have glucose receptors, whereas the cells of almost all hemangiomas do have glucose receptors.  Finally, NICH is different from more common types of hemangiomas because NICH does not spontaneously disappear (involute). Instead, NICH remains stable over time.[1]
Last updated: 12/11/2011

  1. Enjolras O, Mulliken JB, Boon LM, Wassef M, Kozakewich HP, Burrows PE. Noninvoluting congenital hemangioma: a rare cutaneous vascular anomaly. Plastic and Reconstructive Surgery. 2001; 107:1647-1654. Accessed 12/6/2011.