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Genetic and Rare Diseases Information Center (GARD)

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Ameloblastic carcinoma

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What causes ameloblastic carcinoma?

Ameloblastic carcinoma occasionally arises from a preexisting ameloblastoma, but most often occurs sporadically.[1] Ameloblasts are a type of cell that are involved in the development of dental enamel. Once this job is done, the cells usually remain inactive.[2] Ameloblastic carcinoma arises when these cells abnormally start dividing and growing. Exactly what stimulates the excessive cell growth is not well understood. 
Last updated: 10/19/2011

  1. Yoon HJ, Hong SP, Lee JI, Lee SS, Hong SD. Ameloblastic carcinoma: an analysis of 6 cases with review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Dec;108(6):904-13; Accessed 10/18/2011.
  2. Wright JT. Anatomy and development of the teeth. In: Basow, DS. UpToDate. Waltham, MA: UpToDate; 2011;