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Genetic and Rare Diseases Information Center (GARD)

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Logopenic progressive aphasia

Other Names for this Disease
  • Logopenic primary progressive aphasia
  • Logopenic variant PPA
  • LPA
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Your Question

Two questions if I may: Is there any know medications or treatment that can be used for this condition? What can the life expectancy be? 

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is the typical life expectancy for people with logopenic progressive aphasia?

Little is known regarding the overall life expectancy of individuals with logopenic progressive aphasia. This dementia is associated with Alzheimer’s disease in the majority of cases.[1] Life expectancy for people with Alzheimer’s disease has been estimated to be between 3 to 10 years.[2] However, due to the many variables that influence life expectancy, making individualized life-expectancy predictions can be very difficult.
Last updated: 1/18/2013

How might logopenic progressive aphasia be treated?

No medications have been demonstrated to improve or stabilize logopenic progressive aphasia.[3][4][5] So far cholinesterase inhibitors, the drugs used in Alzheimer’s disease, have not been proven effective in treating logopenic progressive aphasia.[4] Behavioral interventions may be helpful in improving communication difficulties.[6]

The National Aphasia Association provides further information on the medical management of primary progressive aphasias at the following link, which you may find helpful:
Last updated: 1/18/2013

  • Hsieh S, Hodges JR, Leyton CE, Mioshi E. Longitudinal changes in primary progressive aphasias: differences in cognitive and dementia staging measures. Dement Geriatr Cogn Disord. 2012;34(2):135-41; Accessed 1/18/2013.
  • Zanetti O, Solerte SB, Cantoni F. Life expectancy in Alzheimer's disease (AD). Arch Gerontol Geriatr. 2009;49 Suppl 1:237-43; Accessed 1/18/2013.
  • Miller BL Lee SE,. Frontotemporal dementia: Treatment. In: DeKosky ST, Eichler AF. UpToDate. Waltham, MA: UpToDate; 2013;
  • Amici S, Gorno-Tempini ML, Ogar JM, Dronkers NF, Miller BL. An overview on Primary Progressive Aphasia and its variants. Behav Neurol. 2006;17(2):77-87; Accessed 1/18/2013.
  • Randolph C . Frontotermporal dementia: Clinical features and diganosis. In: DeKasky ST, Eichler AF. UpToDate. Waltham, MA: UpToDate; 2012;
  • Beeson PM, King RM, Bonakdarpour B, Henry ML, Cho H, Rapcsak SZ. Positive effects of language treatment for the logopenic variant of primary progressive aphasia. J Mol Neurosci. 2011 Nov;45(3):724-36; Accessed 1/18/2013.
  • Le Rhun E, Richard F, Pasquier F. Natural history of primary progressive aphasia. Neurology. 2005 Sep 27;65(6):887-91; Accessed 1/18/2013.