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Genetic and Rare Diseases Information Center (GARD)

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Logopenic progressive aphasia

Other Names for this Disease
  • Logopenic primary progressive aphasia
  • Logopenic variant PPA
  • LPA
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How might logopenic progressive aphasia be treated?

No medications have been demonstrated to improve or stabilize logopenic progressive aphasia.[1][2][3] So far cholinesterase inhibitors, the drugs used in Alzheimer’s disease, have not been proven effective in treating logopenic progressive aphasia.[2] Behavioral interventions may be helpful in improving communication difficulties.[4]

The National Aphasia Association provides further information on the medical management of primary progressive aphasias at the following link, which you may find helpful:
Last updated: 1/18/2013

  1. Miller BL Lee SE,. Frontotemporal dementia: Treatment. In: DeKosky ST, Eichler AF. UpToDate. Waltham, MA: UpToDate; 2013;
  2. Amici S, Gorno-Tempini ML, Ogar JM, Dronkers NF, Miller BL. An overview on Primary Progressive Aphasia and its variants. Behav Neurol. 2006;17(2):77-87; Accessed 1/18/2013.
  3. Randolph C . Frontotermporal dementia: Clinical features and diganosis. In: DeKasky ST, Eichler AF. UpToDate. Waltham, MA: UpToDate; 2012;
  4. Beeson PM, King RM, Bonakdarpour B, Henry ML, Cho H, Rapcsak SZ. Positive effects of language treatment for the logopenic variant of primary progressive aphasia. J Mol Neurosci. 2011 Nov;45(3):724-36; Accessed 1/18/2013.
  5. Le Rhun E, Richard F, Pasquier F. Natural history of primary progressive aphasia. Neurology. 2005 Sep 27;65(6):887-91; Accessed 1/18/2013.
  6. Hsieh S, Hodges JR, Leyton CE, Mioshi E. Longitudinal changes in primary progressive aphasias: differences in cognitive and dementia staging measures. Dement Geriatr Cogn Disord. 2012;34(2):135-41; Accessed 1/18/2013.
  7. Zanetti O, Solerte SB, Cantoni F. Life expectancy in Alzheimer's disease (AD). Arch Gerontol Geriatr. 2009;49 Suppl 1:237-43; Accessed 1/18/2013.

Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied Logopenic progressive aphasia. Click on the link to go to to read descriptions of these studies.