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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Duane syndrome type 1


Other Names for this Disease

  • Duane retraction syndrome 1
  • DURS1
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Treatment

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How might Duane syndrome type 1 be treated?

Management of Duane syndrome is mainly supportive. It may involve treatment of amblyopia ("lazy eye"); wearing glasses or contact lenses; the use of prisms to correct for abnormal head posture; or possible eye muscle surgery.[1][2]

The majority of people with Duane syndrome do not need surgery.[3] However, surgery may be indicated if necessary to reduce severe misalignment of the eyes (strabismus); improve an unacceptable head position; treat a significant upshoot or downshoot; or fix displacement of the eyeball within the orbit (enophthalmos).[3][1]

Unfortunately, surgery does not restore function to the affected nerve and muscle, and no surgical technique has been completely successful in eliminating the abnormal eye movements.[1] Surgery for Duane syndrome usually involves adjusting the other eye muscles to compensate and allow for better eye alignment.[3] While it cannot fix the underlying problem, it can substantially improve signs or symptoms.[3] Some surgical procedures or combinations of procedures may be successful in improving or eliminating head turns and strabismus.[1]
Last updated: 10/29/2014

References
  1. Duane Syndrome. NORD. February 2, 2012; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/224/viewAbstract. Accessed 10/29/2014.
  2. Elizabeth Engle and Sherin Shaaban. Duane retraction syndrome. Orphanet. October, 2013; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=233. Accessed 10/29/2014.
  3. Duane Syndrome. AAPOS. November, 2013; http://www.aapos.org/terms/conditions/46. Accessed 10/29/2014.


Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.

Clinical Trials & Research for this Disease

  • The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.
Other Names for this Disease
  • Duane retraction syndrome 1
  • DURS1
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.