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Diseases

Genetic and Rare Diseases Information Center (GARD)

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ACDC


Other Names for this Disease

  • Arterial calcification and distal joint calcification
  • Arterial calcification due to CD73 deficiency
  • Arterial calcification due to deficiency of CD73
  • Calcification of joints and arteries; CALJA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might ACDC be treated?

Due to the rarity of this condition, there is very limited information available in the medical literature. We are not aware of specific treatment recommendations for ACDC, or of any therapies currently known to be effective. One affected individual reportedly was treated with surgeries to reroute blood flow through alternate vessels and had a joint amputation in the foot.[1] Several possible future therapies have been proposed.[2] Research is currently under way to investigate possible treatment options.

The U.S. National Institutes of Health, through the National Library of Medicine, developed ClinicalTrials.gov to provide patients, family members, and members of the public with current information on clinical research studies. Click here to find trials relating to ACDC. This site may be checked often for new studies, as it is updated regularly.
Last updated: 10/15/2014

References
  1. NIH researchers identify genetic cause of new vascular disease. National Institutes of Health, NIH News. February, 2011; http://rarediseases.info.nih.gov/files/NIH%20ArterialCalcNEJM-final.pdf. Accessed 10/16/2014.
  2. St Hilaire C, et. al. NT5E mutations and arterial calcifications. N Engl J Med. February 3, 2011; 364(5):432-442.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied ACDC. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Arterial calcification and distal joint calcification
  • Arterial calcification due to CD73 deficiency
  • Arterial calcification due to deficiency of CD73
  • Calcification of joints and arteries; CALJA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.