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Genetic and Rare Diseases Information Center (GARD)

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Bone marrow necrosis


* Not a rare disease
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What causes bone marrow necrosis?

Bone marrow necrosis is associated with acute lymphoblastic leukemia (ALL), and is often discovered prior to initial diagnosis or around the time of recurrence of ALL.[1]

Other associated cancers include lymphomas and solid tumors. Chronic myeloproliferative disorders have also been reported in association.  Non-cancerous associated conditions, include infection, tuberculosis, drugs, sickle cell disease, disseminated intravascular coagulation, hemolytic-uremic syndrome, antiphospholipid syndrome, and hyperparathyroidism.[2][1]

Cases of bone marrow necrosis have been reported in association with treatment with anticancer drugs, such as fludarabine, imatinib mesylate, and interferon alfa.[1]

In some cases, the cause of bone marrow necrosis cannot be determined.[2]

Last updated: 4/8/2010

  1. Matsue K, Takeuchi M, Koseki M, Uryu H. Bone marrow necrosis associated with the use of imatinib mesylate in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. Ann Hematol. 2006;
  2. Paydas S, Ergin M, Baslamisli F, Yavuz S, Zorludemir S, Sahin B, Bolat F. Bone marrow necrosis: Clinicopathologic analysis of 20 cases and review of the literature. American Journal of Hematology. 2002;
  3. Inoue S, Monga R, Onwuzurike N. Bone Marrow Necrosis as a presenting feature of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007;