Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Pineal cyst


* Not a rare disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

My wife was diagnosed with a cyst on her pineal gland. We have been researching information and have seen both good and bad things. She's had two MRIs and bloodwork done, and the doctors believe it's benign. What else can we do?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What are pineal cysts?

Pineal cysts are cysts of the pineal gland, a small organ in the brain shaped like the seed of a pine cone that is responsible for making melatonin, a hormone that regulates sleep.  Pineal cysts may be found by chance in up to 10% of people undergoing CT or MRI brain imaging, and they occur in three times more women than men.  Most pineal cysts do not cause symptoms and stay the same size over time (remain stable).[1]  In the rare circumstance where a pineal cyst does cause symptoms, it may cause headaches, hydrocephalus, eye movement abnormalities, and Parinaud syndrome.[2]  Because most pineal cysts do not grow or cause symptoms, there are no established guidelines for routine follow-up for individuals with pineal cysts.  Treatment is usually only considered when a cyst is causing symptoms.[3]  In the past, treatment for symptomatic pineal cysts included surgery to remove the cyst (craniotomy); more recently, less invasive procedures such as stereotactic aspiration or endoscopic treatment have been recommended.[4]
Last updated: 10/16/2012

How might a pineal cyst be managed if it does not cause symptoms?

The best medical management for pineal cysts has yet to be determined.[3]  Because most pineal cysts do not cause symptoms (asymptomatic), some articles do not recommend repeated magnetic resonance imaging (MRI) of the cyst.  They believe that a small cyst (which they define as less than 10-14 millimeters in size) is unlikely to change or cause symptoms later in life; therefore, they suggest that individuals with a pineal cyst have regular clinical check-ups with their personal doctor.[3]  Another article suggested that individuals with a pineal cyst should have a series of several MRIs to prove that the cyst is not growing over time.[1]  However, if at any point new symptoms arise that may be related to the pineal cyst, new imaging should be done of the pineal cyst.[1]
Last updated: 12/29/2011

What are the signs and symptoms of pineal cysts?

Pineal cysts are usually asymptomatic. However, there are rare cases of symptomatic pineal cysts which cause headaches, hydrocephalus, gaze palsy, Parinaud syndrome, and vertigo.[5] Less frequently, patients with symptomatic pineal cysts may present with ataxia, motor and sensory impairment, mental and emotional disturbances, seizures, circadian rhythm disturbances, hypothalamic dysfunction of precocious puberty, and secondary parkinsonism.[6]
Last updated: 12/29/2011

How might symptomatic pineal cysts be treated?

Whether patients with symptomatic pineal cysts should be monitored and/or treated is still unclear.  However, surgery is usually recommended for those people with pineal cysts who have hydrocephalus, worsening neurological symptoms, or enlargement of the cyst over time.[7]  Treatment may include surgery to remove the cyst, sometimes followed by the placement of a ventriculoperitoneal shunt. As of 1993, an alternative treatment option has been aspiration of the contents of the cyst using ultrasound guidance.  More recently, endoscopic procedures have been used.[4]
Last updated: 12/29/2011

  • Fakhran S, Escott EJ. Pineocytoma mimicking a pineal cyst on imaging: true diagnostic dilemma or a case of incomplete imaging?. American Journal of Neuroradiology. 2008; 29:159-163. Accessed 12/13/2011.
  • Al-Holou WN, Maher CO, Muraszko KM, Garton HJL. The natural history of pineal cysts in children and young adults. J. Neurosurg. Pediatrics. 2010;
  • Gaillard F, Jones J. Masses of the pineal region: clinical presentation and radiographic features. Postgraduate Medical Journal. 2010; 86:597-607. Accessed 12/13/2011.
  • Costa F, Fornari M, Valla P, Servello D. Symptomatic Pineal Cyst: Case Report and Review of the Literature. Minim. Invas. Neurosurg.. 2008; 51:231-233.
  • Wajd NA, Maher CO, Muraszko KM, Garton HJL. The natural history of pineal cysts in children and young adults. J. Neurosurg. Pediatrics. 2010;
  • Bosnjak J, Budisic M, Azman D, Strineka M, Crnjakovic M, Demarin V. Pineal gland cysts--an overview. Acta Clin Croat. 2009;
  • Taraszewska A, Matyja E, Koszewki W, Zaczynski A, Bardadin K, Czernicki Z. Asymptomatic and symptomatic glial cysts of the pineal gland. Folia Neuropathol. 2008;