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Your QuestionMy wife was diagnosed by MRI with probable myxopapillary ependymoma. The specialist is recommending surgery; are there any other treatment options?
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Standard treatment of myxopapillary ependymoma is aggressive surgery. It can generally can be cured by gross total surgical resection, and there is usually a favorable prognosis. However, surgery is typically less curative in tumors that are large, multifocal or extend outside the thecal sac. Late recurrences may occur, particularly in pediatric individuals. Treatment strategies may also include radiation, but the use of chemotherapy remains more controversial; chemotherapy has been widely used in pediatric individuals due to more aggressive disease in these individuals. The role of adjuvant chemotherapy or radiotherapy is unclear for the subset of individuals with recurrence or in individuals in whom gross total resection cannot be achieved.
Last updated: 6/8/2011
- Valerie N Barton et al. Unique Molecular Characteristics of Pediatric Myxopapillary Ependymoma. Brain Pathology. May 2010; 20(3):560-570. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871180/?tool=pubmed. Accessed 4/7/2011.
- Shonka NA. Targets for therapy in ependymoma. Targeted Oncology. March 29, 2011; Epub:http://www.ncbi.nlm.nih.gov/pubmed/21445635. Accessed 4/7/2011.