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Genetic and Rare Diseases Information Center (GARD)

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* Not a rare disease
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Lipedema is a syndrome characterized by symmetric enlargement of the legs due to deposits of fat beneath the skin, which is often painful.  It is a common condition affecting up to 11% of women  The underlying cause is currently unknown; however many people with lipedema have a family history of similarly enlarged legs. Hormones are also thought to play a role.[1][2]
Last updated: 7/12/2011


  1. Fonder MA, Loveless JW, Lazarus GS.. Lipedema, a frequently unrecognized problem. J Am Acad Dermatol. 2007; 57 (2 Suppl):S1-3. Accessed 7/12/2011.
  2. Lipoedema. DermNet NZ. June 2009; Accessed 7/12/2011.
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by the Genetic and Rare Diseases Information Center

1 question(s) from the public on Lipedema have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.

In Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Lipedema. Click on the link to view a sample search on this topic.