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Genetic and Rare Diseases Information Center (GARD)

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* Not a rare disease
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What are the signs and symptoms of lipedema?

Signs and symptoms of lipedema include enlarged legs extending from the buttocks to the ankles. This enlargement can be painful. The size of the legs are typically out of proportion to the upper body (despite the individual’s BMI). The feet are much less involved or spared entirely. In lipedema, the skin does not appear warty, hard (sclerotic), or discolored. Lipedema is not thought to predispose a person to ulcer development.[1] People with lipedema may tend to bruise easily, possibly due to increased fragility of small blood vessel within the fat tissue.[2]
Last updated: 7/12/2011

  1. Fonder MA, Loveless JW, Lazarus GS.. Lipedema, a frequently unrecognized problem. J Am Acad Dermatol. 2007; 57 (2 Suppl):S1-3. Accessed 7/12/2011.
  2. Wyatt L, Pribaz J. Lymphedema. In: Abeloff. Abeloff's Clinical Oncology, 4th ed. Philadelphia, PA: Churchill Livingstone; 2008;