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Genetic and Rare Diseases Information Center (GARD)

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Twenty-nail dystrophy

Other Names for this Disease
  • Onychodystrophy totalis, isolated
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Twenty-nail dystrophy is a condition that affects the nails of the fingers and toes.  The surface of all twenty nails develop ridges, splitting, and roughening (similar to sandpaper).  The nails may also be dull and brittle. This condition most commonly occurs in childhood, but it can occur at any age.  The exact cause is unknown; but in some cases, it appears to be associated with other skin conditions such as lichen planus, eczema, psoriasis and alopecia areata. Many cases of twenty-nail dystrophy that begin gradually in early childhood tend to disappear naturally as the child ages.[1][2]
Last updated: 7/4/2012


  1. Twenty-nail dystrophy. DermNet NZ. June 2009; Accessed 12/8/2011.
  2. Sehgal VN. Twenty nail dystrophy trachyonychia: an overview. Journal of Dermatology. 2007; 34:361-366. Accessed 7/4/2012.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Twenty-nail dystrophy. Click on the link to view a sample search on this topic.