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Acquired hemophilia
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Overview
Acquired hemophilia is a rare form of hemophilia in which the body makes specialized proteins called autoantibodies that attack and disable coagulation factors (proteins in the blood that assist with the clotting process).[1] The most common coagulation factor attacked is coagulation factor VIII, though other coagulation factors, including factor V and factor IX have been associated with the condition.[2] The production of autoantibodies is sometimes associated with pregnancy, immune system disorders (e.g., systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome), viral infections cancer, or allergic reactions to certain drugs.[1][2] In about half of cases, the cause of acquired hemophilia is unknown.[1] Treatment may vary from person to person.
References
- Hemophilia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition=hemophilia. Accessed June 16, 2011.
- Zeitler H, Ulrich-Merzenich G, Hess L, Konsek E, Unkrig C, Walger P, et al. Blood. 2005. http://bloodjournal.hematologylibrary.org/cgi/reprint/105/6/2287. Accessed October 14, 2008.
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General Information
- Genetics Home Reference (GHR) contains information on Acquired hemophilia. Click on the link to go to GHR and review the information.
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- !LINK! is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Acquired hemophilia. Click on the link to view a sample search on this topic.