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Genetic and Rare Diseases Information Center (GARD)

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Diffuse gastric cancer

Other Names for this Disease
  • Signet cell adenocarcinoma
  • Signet ring cell carcinoma
  • Signet ring cell gastric carcinoma
  • Signet ring gastric carcinoma
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Can diffuse gastric cancer be inherited?

Diffuse gastric cancer can be inherited or can happen sporadically in a family. Sporadic means that the cancer occurred randomly for the first time in a individual and was not inherited from a parent. Hereditary diffuse gastric cancer (HDGC) is caused by mutations in the CDH1 gene. Individuals with a CDH1 mutation typically develop cancer before age 40.[1]
Last updated: 12/16/2011

  1. Kaurah P, Huntsman DG. Hereditary diffuse gastric cancer. GeneReviews. June 2011; Accessed 9/30/2011.