Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Diffuse gastric cancer

Other Names for this Disease
  • Signet cell adenocarcinoma
  • Signet ring cell carcinoma
  • Signet ring cell gastric carcinoma
  • Signet ring gastric carcinoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


What is diffuse gastric cancer?

Can diffuse gastric cancer be inherited?

What is diffuse gastric cancer?

Diffuse gastric cancer is a type of cancer found most often in the glandular cells lining the stomach, but can also develop in the bowel, breast, pancreas, bladder, prostate or lung. The term "signet ring cell" is often used because the cells look like signet rings when viewed under a microscope. The signet cells are a type of epithelial cell. Epithelial tissue is skin tissue, covering and lining the body both inside and out.[1] 
Last updated: 12/16/2011

Can diffuse gastric cancer be inherited?

Diffuse gastric cancer can be inherited or can happen sporadically in a family. Sporadic means that the cancer occurred randomly for the first time in a individual and was not inherited from a parent. Hereditary diffuse gastric cancer (HDGC) is caused by mutations in the CDH1 gene. Individuals with a CDH1 mutation typically develop cancer before age 40.[2]
Last updated: 12/16/2011

  1. Signet cell cancer. Cancer Research UK's Website. February 2011; Accessed 9/30/2011.
  2. Kaurah P, Huntsman DG. Hereditary diffuse gastric cancer. GeneReviews. June 2011; Accessed 9/30/2011.