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Genetic and Rare Diseases Information Center (GARD)

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Syndrome of inappropriate antidiuretic hormone

*

* Not a rare disease

Other Names for this Disease

  • Dilutional hyponatremia
  • Inappropriate ADH syndrome
  • Schwartz Bartter syndrome
  • SIADH
  • Syndrome of inappropriate antidiuretic hormone secretion
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

The doctor told me I have SIADH or syndrome of inappropriate antidiuretic hormone. I would like to know more about it.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is antidiuretic hormone?

Antidiuretic hormone is a hormone that is produced in a part of the brain called the hypothalamus. It is then stored and released from the pituitary gland, a small gland at the base of the brain.[1] It is involved in regulating sodium levels in the blood and water volume in the body.[1][2] 
Last updated: 6/5/2014

What is syndrome of inappropriate antidiuretic hormone?

Syndrome of inappropriate antidiuretic hormone (SIADH) occurs when an excessive amount of antidiuretic hormone is released resulting in water retention and a low sodium level. It is most common among older people. It has many causes including, but not limited too, pain, stress, exercise, a low blood sugar level, certain disorders of the heart, thyroid gland, kidneys, or adrenal glands, and the use of certain medications. Disorders of the lungs and certain cancers may increase the risk of developing SIADH. Treatment includes fluid restriction and sometimes the use of medications that decrease the effect of antidiuretic hormone on the kidneys.[2]
Last updated: 6/5/2014

What are the symptoms of syndrome of inappropriate antidiuretic hormone?

Symptoms of syndrome of inappropriate antidiuretic hormone include water retention and low sodium level. Low sodium levels may cause lethargy and confusion. Severe low levels of sodium in the body may cause muscle twitching, seizures, stupor, coma, and death.[2]
Last updated: 6/5/2014

How might the syndrome of inappropriate antidiuretic hormone be treated?

Treatment of syndrome of inappropriate antidiuretic hormone (SIADH) may involve fluid restriction, treatment of the underlying cause once determined, and medication that decreases the effect of antidiuretic hormone on the kidneys. [2]
Last updated: 6/5/2014

What causes syndrome of inappropriate antidiuretic hormone?

Many things can cause syndrome of inappropriate antidiuretic hormone (SIADH), including brain injury, brain infection, brain abscesses, subarachnoid hemorrhage, encephalitis, meningitis, Guillain-Barré syndrome, delirium tremens, multiple sclerosis, lung cancer, pancreatic cancer, thymoma, ovarian cancer, lymphoma,  pneumonia, chronic obstructive pulmonary disease, lung abscess, tuberculosis, cystic fibrosis, surgery, and drugs.[3]

SIADH has also been reported in association with AIDS, temporal arteritis, polyarteritis nodosa, sarcoidosis, Rocky Mountain spotted fever, carcinoma of the cervix, olfactory neuroblastoma, and herpes zoster infection of the chest wall.[3]

Often the underlying cause of the condition can not be determined. In these cases the condition is said to be idiopathic.

Last updated: 6/5/2014

References
Other Names for this Disease
  • Dilutional hyponatremia
  • Inappropriate ADH syndrome
  • Schwartz Bartter syndrome
  • SIADH
  • Syndrome of inappropriate antidiuretic hormone secretion
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.