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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Neu Laxova syndrome


Other Names for this Disease
  • NLS
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Your Question

I had a sibling with Neu-Laxova and I was always told growing up that I would have a 1 in 4 chance of having a child with this condition. I was wondering if that probability was still the same?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How is Neu-Laxova syndrome inherited?

Neu-Laxova is inherited in an autosomal recessive manner.[1] Both parents would need to carry one copy of the mutated gene for the condition in order to have a child with Neu-Laxova.  For an individual that has a sibling with Neu-Laxova, the chance of being of carrier is 2/3.  Two carriers have a 1 in 4 (25%) chance with each pregnancy of having a child affected by the condition. We strongly recommend you discuss your concerns with a genetics professional to determine your specific risks of being a carrier and having a child with this condition.
Last updated: 8/1/2012

References
  • Manning MA, Cunniff CM, Colby CE. Neu-Laxova syndrome: detailed prenatal diagnostic and post-mortem findings and literature review. Am J Med Genet. 2004; 3:240-9. http://www.ncbi.nlm.nih.gov/pubmed/14994231. Accessed 8/1/2012.