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Genetic and Rare Diseases Information Center (GARD)

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Hemoglobin Zurich


Other Names for this Disease

  • Hb-Zurich
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Overview

Hemoglobin (Hb) Zurich is an inherited blood disorder. People with Hb Zurich have an abnormal form of Hb, a red blood cell (RBC) protein that binds to oxygen in the lungs. This abnormal Hb more readily binds to carbon monoxide (producing carboxyhemoglobin or COHb).[1] Normally the level of COHb is less than 1-2% in adults. People with Hb Zurich tend to have COHb levels above 3%.[2] The health effects of Hb Zurich tend to be mild compared to other inherited blood cell disorders.[3] Symptoms usually develop only when the body is stressed due to an infection or fever or when exposed to certain drugs. Symptoms develop as a result of the premature breakdown of RBC (hemolytic anemia). Click here to visit MedlinePlus.gov and view an illustration of hemoglobin.
Last updated: 3/20/2014

References

  1. Steinberg MH. Unstable hemoglobin variants. In: Basow M. UpToDate. Waltham, MA: UpToDate; 2014; Accessed 3/20/2014.
  2. Steinberg MH, Orget BG, Higgs DR, Veatherall DJ. Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management. Oxford: Cambridge University; August 2009; Accessed 3/20/2014.
  3. Benz EJ Jr, Ebert BL. Hemoglobin Variants Associated With Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias. In: Hoffman. Hematology: Basic Principles and Practice, 6th ed. 2012; Accessed 3/20/2014.
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In Depth Information

  • PubMed is a searchable database of medical literature and lists journal articles that discuss Hemoglobin Zurich. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Hb-Zurich
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.