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Genetic and Rare Diseases Information Center (GARD)

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Hereditary leiomyomatosis and renal cell cancer

Other Names for this Disease
  • Familial leiomyomatosis
  • LRCC
  • MCL
  • MCUL
More Names
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What are the signs and symptoms of hereditary leiomyomatosis and renal cell cancer?

Signs and symptoms of hereditary leiomyomatosis and renal cell cancer (HLRCC) typically begin in adulthood at an average age of 25. The skin growths (cutaneous leiomyomata) appear as skin-colored or light brown bumps on the torso and extremities, and occasionally on the face. They usually increase in size and number with age. They may be more sensitive than the surrounding skin and be painful. Uterine leiomyomata (fibroids) also occur in almost all affected women and tend to be large and numerous. Most women with these have irregular or heavy periods and pelvic pain. A renal tumor occurs in about 10% to 16% of affected individuals (at an average age of 44 years) and may cause blood in the urine, lower back pain, and a palpable mass. Some people with renal cell cancer have no symptoms until the cancer is advanced.[1][2]
Last updated: 1/9/2014

  1. Hereditary leiomyomatosis and renal cell cancer. Genetics Home Reference. April 2008; Accessed 6/30/2009.
  2. Manop Pithukpakorn and Jorge R Toro. Hereditary Leiomyomatosis and Renal Cell Cancer. GeneReviews. November 2, 2010; Accessed 1/9/2014.