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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Corneal dystrophy Fuchs endothelial 1


Other Names for this Disease

  • Corneal dystrophy Fuchs endothelial early-onset
  • Early-onset Fuchs endothelial corneal dystrophy
  • FECD1
  • Fuchs endothelial corneal dystrophy 1
  • Fuchs' endothelial dystrophy type 1
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Inheritance

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How is Fuchs dystrophy inherited?

The inheritance of Fuchs dystrophy is not straight forward. In some cases, Fuchs dystrophy appears to be inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. When this condition is caused by a mutation in the COL8A2 gene, it is inherited in an autosomal dominant pattern. In addition, an autosomal dominant inheritance pattern is seen in some situations in which the condition is caused by changes in an unknown gene. However, in many cases, the inheritance pattern is unknown. Some cases result from new mutations in a gene and occur in people with no history of the disorder in their family. Due to the complex nature of the inheritance of this condition, we strongly recommend you discuss your concerns with a genetics professional.[1]
Last updated: 4/10/2014

References
  1. Fuchs endothelial dystrophy. Genetics Home Reference. June 2011; http://ghr.nlm.nih.gov/condition/fuchs-endothelial-dystrophy. Accessed 4/10/2014.


Other Names for this Disease
  • Corneal dystrophy Fuchs endothelial early-onset
  • Early-onset Fuchs endothelial corneal dystrophy
  • FECD1
  • Fuchs endothelial corneal dystrophy 1
  • Fuchs' endothelial dystrophy type 1
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.